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fentanyl transdermal and diazepam each raise sedation. Prevent or Use Alternate Drug. Limit use to individuals for whom choice remedy choices are inadequateapalutamide will reduce the level or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer,